Fenbendazole is a common anthelmintic that kills parasites and some worms (roundworms, giardia, hookworms, whipworms and pinworms) in animals. It is also used as a treatment for non-melanoma skin cancers.
The anti-cancer effect of fenbendazole is due to its binding to and blocking the polymerization of tubulin dimers, which are critical for cell division. It also blocks glucose absorption in cancer cells. Cancer cells rely on aerobic glycolysis, which uses up glucose 200 times faster than normal cells. This can be seen on PET scans, where metabolically active tumors use up radioactive glucose at higher rates.
To test whether fenbendazole might protect against radiation-induced cytotoxicity in EMT6 colon carcinoma cells, cultures were treated with either fenbendazole or control for 2 h. Subsequently, the cultures were exposed to graded doses of x-rays. The number of colonies that survived each exposure was determined. The results show that the fenbendazole protected against radiation-induced cytotoxicity in EMT6 cells at concentrations up to 10 mM.
Sanare lab fenbendazole is a freeze-dried nanoparticle emulsion of a molecule of fenbendazole loaded into polymeric micelles. This unique delivery system was created for research into repurposed usage of this broad-spectrum antiparasitic medication. It can be taken orally and is available in pill form from 3rd party sellers on Amazon or eBay as Panacur / Safeguard. Our fenbendazole is laboratory tested to ensure purity and consistency. People with severe liver or kidney failure have lower medication excretion rates, so it is important to take a dosage that is appropriate for your level of health and avoid overdosing. A schedule of three days on and four days off seems to work well for many people.